Concept information
Terme préférentiel
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Type
-
mesh:Descriptor
Définition
- A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Concept générique
Synonyme(s)
- 25-Hydroxycholecalciferol 1-Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
- CYP27B1
- Cytochrome P-450 CYP27B1
Qualificatif(s) autorisé(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
Traductions
-
français
-
25-Hydroxycholécalciférol 1-hydroxylase
-
Calcidiol 1-Monooxygénase
-
Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
-
CYP 27B1
-
CYP27B1
-
Cytochrome P-450 CYP27B1
-
Cytochrome P450 27B1
URI
http://data.loterre.fr/ark:/67375/JVR-F1J1QCL5-M
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