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Concept information

... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases > 11-beta-Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenase Type 2
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenase Type 2

Terme préférentiel

11-beta-Hydroxysteroid Dehydrogenase Type 2  

Type

  • mesh:Descriptor

Définition

  • An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

Concept générique

Synonyme(s)

  • 11 beta-HSD2
  • 11beta-HSD2
  • 11beta-HSD2 Reductase
  • 11 beta-Hydroxysteroid Dehydrogenase Type 2
  • 11beta-Hydroxysteroid Dehydrogenase Type 2

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-F6058FJC-3

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RDF/XML TURTLE JSON-LD Date de création 09/07/2003, dernière modification le 08/07/2013