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Concept information

Genetic Phenomena > DNA Damage

Terme préférentiel

DNA Damage  

Type

  • mesh:Descriptor

Définition

  • Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. DNA DAMAGE in vivo.

Concept générique

Concepts spécifiques

Concepts associés

Synonyme(s)

  • DNA Injury
  • Injury, DNA

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-GM3G5SW3-M

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RDF/XML TURTLE JSON-LD Date de création 19/06/1986, dernière modification le 17/06/2016