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Concept information

Terme préférentiel

Chromatin Immunoprecipitation  

Type

  • mesh:Descriptor

Définition

  • A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

Synonyme(s)

  • Immunoprecipitation, Chromatin

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-GW73DX76-6

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RDF/XML TURTLE JSON-LD Date de création 19/07/2004