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Concept information

Endocrine System Diseases > Gonadal Disorders > Puberty, Precocious

Terme préférentiel

Puberty, Precocious  

Type

  • mesh:Descriptor

Définition

  • Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. An autosomal dominant hereditary disorder that is characterized by gonadotropin-dependent precocious puberty due to early activation of the hypothalamic-pituitary-gonadal axis. A mutation in the KISS1R gene has been identified. OMIM: 176400 Familial precocious puberty in boys usually presents by age 4 with rapid VIRILIZATION and is also characterized by gonadotropin-independent testosterone secretion, low secretion of LUTEINIZING HORMONE, and advanced SPERMATOGENESIS in the testis. Mutations in the LHCGR gene have been identified. OMIM: 176410

Concept générique

Concepts associés

Synonyme(s)

  • Precocious Puberty
  • Pubertas Praecox

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-H72FRBKH-P

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RDF/XML TURTLE JSON-LD Date de création 01/01/1999, dernière modification le 28/02/2018