Passer au contenu principal

Medical Subject Headings (thesaurus)

Choisissez le vocabulaire dans lequel chercher

aligner
annoter
télécharger

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > NFATC Transcription Factors

Terme préférentiel

NFATC Transcription Factors  

Type

  • mesh:Descriptor

Définition

  • A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. A signal-dependent transcription factor that controls cellular response to osmotic stress. NFAT5 is closely related to NFATC PROTEINS but resides constitutively in the CELL NUCLEUS and operates independently of CALCINEURIN and TRANSCRIPTION FACTOR AP-1.

Concept générique

Synonyme(s)

  • NFATC Proteins
  • NF-AT Proteins
  • NFAT Proteins
  • Nuclear Factor of Activated T-Cells, Cytoplasmic
  • Nuclear Factors of Activated T-Cells
  • Transcription Factor NF-AT

Qualificatif(s) autorisé(s)

Traductions

  • Facteurs de transcription NFATC

    français

  • Facteur de transcription NF-AT
  • Facteur transcriptionnel NF-AT
  • Facteurs nucléaires des cellules T activées
  • Facteurs nucléaires des lymphocytes T activés
  • Facteurs transcriptionnels NFATC
  • Protéines NF-AT
  • Protéines NFAT
  • Protéines NFATC

URI

http://data.loterre.fr/ark:/67375/JVR-JHK3X299-6

Télécharger ce concept :

RDF/XML TURTLE JSON-LD Date de création 30/06/2005, dernière modification le 09/07/2013