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Concept information

Biological Factors > Toxins, Biological > Enterotoxins > Cholera Toxin
Biological Factors > Toxins, Biological > Bacterial Toxins > Cholera Toxin
... > Enzymes and Coenzymes > Enzymes > Transferases > Glycosyltransferases > Pentosyltransferases > ADP Ribose Transferases > Cholera Toxin

Terme préférentiel

Cholera Toxin  

Type

  • mesh:Descriptor

Définition

  • An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. The nontoxic, pentameric B protomer of cholera toxin. The cell membrane binding component of cholera toxin. Detoxified aggregate of cholera toxin formed by heat treatment of purified cholera toxin. The catalytic subunit of cholera toxin. It is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE.

Concept générique

Concepts associés

Synonyme(s)

  • 9012-63-9
  • Cholera Enterotoxin CT
  • Cholera Exotoxin
  • Choleragen

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Toxine cholérique

    français

  • 9012-63-9
  • Choléragène
  • Entérotoxine cholérique
  • Exotoxine cholérique

URI

http://data.loterre.fr/ark:/67375/JVR-K928J3KP-8

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RDF/XML TURTLE JSON-LD Date de création 22/04/1977, dernière modification le 30/06/2021