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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > Proto-Oncogene Proteins c-abl
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Proto-Oncogene Proteins c-abl
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Proto-Oncogene Proteins c-abl
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Proto-Oncogene Proteins c-abl

Terme préférentiel

Proto-Oncogene Proteins c-abl  

Type

  • mesh:Descriptor

Définition

  • Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

Concept générique

Concepts spécifiques

Concepts associés

Synonyme(s)

  • abl Proto-Oncogene Products
  • abl Proto-Oncogene Proteins
  • c-abl Proteins
  • Proto-Oncogene Proteins abl

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-KGSX5203-N

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RDF/XML TURTLE JSON-LD Date de création 19/06/1990, dernière modification le 21/05/2021