Concept information
Terme préférentiel
Complement Pathway, Alternative
Type
-
mesh:Descriptor
Définition
- Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Concept générique
Synonyme(s)
- Alternative Complement Activation Pathway
- Alternative Complement Pathway
- Complement Activation Pathway, Alternative
- Properdin Pathway
Qualificatif(s) autorisé(s)
Traductions
-
français
-
Voie alterne du complément
-
Voie de la properdine
URI
http://data.loterre.fr/ark:/67375/JVR-LFC9WKNQ-6
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