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Concept information

Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Fanconi Anemia Complementation Group N Protein
Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Fanconi Anemia Complementation Group N Protein
Amino Acids, Peptides, and Proteins > Proteins > Fanconi Anemia Complementation Group Proteins > Fanconi Anemia Complementation Group N Protein

Terme préférentiel

Fanconi Anemia Complementation Group N Protein  

Type

  • mesh:Descriptor

Définition

  • A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

Concept générique

Synonyme(s)

  • FANCN Protein
  • PALB2 Protein
  • Partner and Localizer of BRCA2 Protein

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-LM46JH52-F

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RDF/XML TURTLE JSON-LD Date de création 11/07/2017, dernière modification le 29/06/2017