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Concept information

Enzymes and Coenzymes > Enzymes > Isomerases > DNA Helicases > X-linked Nuclear Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > Adenosine Triphosphatases > DNA Helicases > X-linked Nuclear Protein

Terme préférentiel

X-linked Nuclear Protein  

Type

  • mesh:Descriptor

Définition

  • ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).

Concept générique

Concepts associés

Synonyme(s)

  • ATRX Protein
  • RAD54 Homolog Protein

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-MDCL02LQ-D

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RDF/XML TURTLE JSON-LD Date de création 11/07/2017, dernière modification le 29/06/2017