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Concept information

... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Nedd4 Ubiquitin Protein Ligases
Macromolecular Substances > Multiprotein Complexes > Endosomal Sorting Complexes Required for Transport > Nedd4 Ubiquitin Protein Ligases
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Vesicular Transport Proteins > Endosomal Sorting Complexes Required for Transport > Nedd4 Ubiquitin Protein Ligases

Terme préférentiel

Nedd4 Ubiquitin Protein Ligases  

Type

  • mesh:Descriptor

Définition

  • E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

Concept générique

Synonyme(s)

  • Nedd4 Proteins
  • Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase

Qualificatif(s) autorisé(s)

Traductions

  • Ubiquitine protéine ligases NEDD4

    français

  • Ligase-4 exprimée par les précursseurs des cellules neurales régulée négativement au cours du développement
  • Protéines NEDD4
  • Ubiquitine ligases NEDD4

URI

http://data.loterre.fr/ark:/67375/JVR-MR615SKC-F

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RDF/XML TURTLE JSON-LD Date de création 11/07/2017, dernière modification le 29/06/2017