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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1

Terme préférentiel

Kelch-Like ECH-Associated Protein 1  

Type

  • mesh:Descriptor

Définition

  • An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.

Concept générique

Synonyme(s)

  • KEAP-1 Protein
  • KEAP1 Protein

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-N858M3F3-C

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RDF/XML TURTLE JSON-LD Date de création 08/07/2016, dernière modification le 27/05/2016