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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Cyclin-Dependent Kinase Inhibitor Proteins

Terme préférentiel

Cyclin-Dependent Kinase Inhibitor Proteins  

Type

  • mesh:Descriptor

Définition

  • A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION. A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. INK4 proteins bind to CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. They dissociate cyclin-CDK complexes and regulate a CELL CYCLE checkpoint in early G1 PHASE.

Concept générique

Concepts spécifiques

Synonyme(s)

  • CDKI Proteins
  • CKI Proteins
  • Cyclin-Kinase Inhibitor Proteins

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Protéines inhibitrices des kinases cyclines-dépendantes

    français

  • CDKI
  • CKI (Cyclin-dependent Kinase Inhibitor)
  • CKI (Cyclin-Kinase Inhibitor)
  • Cyclin-dependent kinase inhibitor
  • Cyclin-kinase inhibitor
  • Protéines CDKI
  • Protéines CKI
  • Protéines inhibitrices des CDK
  • Protéines inhibitrices des kinases dépendantes des cyclines

URI

http://data.loterre.fr/ark:/67375/JVR-P5K3DBDP-J

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RDF/XML TURTLE JSON-LD Date de création 30/06/2005, dernière modification le 23/11/2015