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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins

Terme préférentiel

Insulin Receptor Substrate Proteins  

Type

  • mesh:Descriptor

Définition

  • A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

Concept générique

Synonyme(s)

  • IRS Signaling Adaptor Proteins

Qualificatif(s) autorisé(s)

Traductions

  • Substrats du récepteur à l'insuline

    français

  • Protéines adaptatrices IRS
  • Protéines IRS
  • Substrats du récepteur d'insuline
  • Substrats du récepteur insulinique
  • Substrats protéiques du récepteur d'insuline

URI

http://data.loterre.fr/ark:/67375/JVR-PCCM714Q-7

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RDF/XML TURTLE JSON-LD Date de création 08/07/2008, dernière modification le 24/05/2017