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Concept information

Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine

Terme préférentiel

Zidovudine  

Type

  • mesh:Descriptor

Définition

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Concept générique

Synonyme(s)

  • 30516-87-1 (Zidovudine)
  • 3'-Azido-2',3'-Dideoxythymidine
  • 3'-Azido-3'-deoxythymidine
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Antiviral)
  • AZT Antiviral
  • AZT, Antiviral
  • Thymidine, 3'-azido-3'-deoxy-

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Zidovudine

    français

  • 3'-Azido-3'-désoxy-thymidine
  • 3'-Azido-3'-désoxythymidine
  • 30516-87-1 (Zidovudine)
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Azidothymidine)
  • Thymidine, 3'-azido-3'-deoxy-

URI

http://data.loterre.fr/ark:/67375/JVR-PLNR7NBH-G

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RDF/XML TURTLE JSON-LD Date de création 09/05/1988, dernière modification le 01/06/2016