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Concept information

... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Aspartic Acid Endopeptidases > Endothelin-Converting Enzymes
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Aspartic Acid Proteases > Aspartic Acid Endopeptidases > Endothelin-Converting Enzymes
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > Endothelin-Converting Enzymes
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > Endothelin-Converting Enzymes

Terme préférentiel

Endothelin-Converting Enzymes  

Type

  • mesh:Descriptor

Définition

  • Metalloendopeptidases which convert BIG ENDOTHELIN to ENDOTHELIN-1. Converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond. Mutations in the endothelin-converting enzyme 1 (ECE1) gene are associated with cases of HIRSCHSPRUNG DISEASE with cardiac defects and autonomic dysfunction. An integral membrane metalloendodpeptidase which converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond . It is also involved in the processing of various neuroendocrine peptides and may have methyltransferase activity.

Concept générique

Synonyme(s)

  • Endothelin Converting Enzyme
  • Endothelin-Converting Enzyme

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-PQBVQRFZ-N

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RDF/XML TURTLE JSON-LD Date de création 08/07/2016, dernière modification le 27/05/2016