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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Tuberous Sclerosis Complex 1 Protein
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Tuberous Sclerosis Complex 1 Protein
Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Tuberous Sclerosis Complex 1 Protein

Terme préférentiel

Tuberous Sclerosis Complex 1 Protein  

Type

  • mesh:Descriptor

Définition

  • An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.

Concept générique

Synonyme(s)

  • Hamartin

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-QZQDLP50-T

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RDF/XML TURTLE JSON-LD Date de création 09/07/2018, dernière modification le 29/04/2019