Passer au contenu principal

Medical Subject Headings (thesaurus)

Choisissez le vocabulaire dans lequel chercher

aligner
annoter
télécharger

Concept information

Chemical Actions and Uses > Pharmacologic Actions > Therapeutic Uses > Antineoplastic Agents > Antineoplastic Agents, Alkylating
Chemical Actions and Uses > Toxic Actions > Noxae > Alkylating Agents > Antineoplastic Agents, Alkylating
Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Alkylating Agents > Antineoplastic Agents, Alkylating

Terme préférentiel

Antineoplastic Agents, Alkylating  

Type

  • mesh:Descriptor

Définition

  • A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Concept générique

Synonyme(s)

  • Alkylating Agents, Antineoplastic
  • Alkylating Antineoplastic Agents
  • Alkylating Antineoplastic Drugs
  • Alkylating Antineoplastics
  • Alkylating Drugs, Antineoplastic
  • Antineoplastic Alkylating Agents
  • Antineoplastic Drugs, Alkylating
  • Antineoplastics, Alkylating

Qualificatif(s) autorisé(s)

Traductions

  • Antinéoplasiques alcoylants

    français

  • Agents anticancéreux alkylants
  • Anticancéreux alcoylants
  • Anticancéreux alkylants
  • Antinéoplasiques alkylants

URI

http://data.loterre.fr/ark:/67375/JVR-RH7RGR6D-2

Télécharger ce concept :

RDF/XML TURTLE JSON-LD Date de création 26/05/1995, dernière modification le 25/06/2014