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Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Viral Proteins > Retroviridae Proteins > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Oncogene Proteins, Viral > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA
... > Amino Acids, Peptides, and Proteins > Proteins > Viral Proteins > Oncogene Proteins, Viral > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA

Terme préférentiel

Oncogene Proteins v-erbA  

Type

  • mesh:Descriptor

Définition

  • Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

Concept générique

Concepts associés

Synonyme(s)

  • erbA Oncogene Proteins
  • Oncogene Products v-erbA
  • v-erbA Proteins

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-SCVKTDFZ-Q

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RDF/XML TURTLE JSON-LD Date de création 23/05/1994, dernière modification le 01/07/2018