Passer au contenu principal

Medical Subject Headings (thesaurus)

Choisissez le vocabulaire dans lequel chercher

aligner
annoter
télécharger

Concept information

Genetic Phenomena > Gene Expression Regulation > Epigenesis, Genetic > Gene Silencing > RNA Interference

Terme préférentiel

RNA Interference  

Type

  • mesh:Descriptor

Définition

  • A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process. Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE.

Concept générique

Concepts associés

Synonyme(s)

  • Gene Silencing, Post-Transcriptional
  • Post-Transcriptional Gene Silencing
  • Posttranscriptional Gene Silencing
  • RNAi
  • RNA Silencing

Qualificatif(s) autorisé(s)

Traductions

  • Interférence par ARN

    français

  • Extinction des ARN
  • Inactivation génique post-transcriptionnelle
  • Inactivation post-transcriptionnelle des gènes
  • Interférence ARN

URI

http://data.loterre.fr/ark:/67375/JVR-SD19LFDC-7

Télécharger ce concept :

RDF/XML TURTLE JSON-LD Date de création 03/07/2002, dernière modification le 17/06/2016