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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Proteinase Inhibitory Proteins, Secretory > Tissue Inhibitor of Metalloproteinases > Tissue Inhibitor of Metalloproteinase-2
Amino Acids, Peptides, and Proteins > Proteins > Proteinase Inhibitory Proteins, Secretory > Tissue Inhibitor of Metalloproteinases > Tissue Inhibitor of Metalloproteinase-2

Terme préférentiel

Tissue Inhibitor of Metalloproteinase-2  

Type

  • mesh:Descriptor

Définition

  • A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

Concept générique

Synonyme(s)

  • 127497-59-0
  • TIMP-2

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-T0JDS5TH-V

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RDF/XML TURTLE JSON-LD Date de création 30/06/1997, dernière modification le 03/07/2012