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Concept information

Biological Factors > Toxins, Biological > Mycotoxins > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Benzopyrans > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrans > Benzopyrans > Aflatoxins > Aflatoxin M1

Terme préférentiel

Aflatoxin M1  

Type

  • mesh:Descriptor

Définition

  • A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Concept générique

Synonyme(s)

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxyaflatoxin B1
  • 6795-23-9
  • Aflatoxin M(1)
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Aflatoxine M1

    français

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxy-aflatoxine B1
  • 6795-23-9
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

URI

http://data.loterre.fr/ark:/67375/JVR-T72WT1C3-T

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RDF/XML TURTLE JSON-LD Date de création 25/01/1991, dernière modification le 27/05/2020