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Concept information

... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Tripartite Motif-Containing Protein 28
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Tripartite Motif-Containing Protein 28
Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Tripartite Motif-Containing Protein 28
Amino Acids, Peptides, and Proteins > Proteins > Tripartite Motif Proteins > Tripartite Motif-Containing Protein 28

Terme préférentiel

Tripartite Motif-Containing Protein 28  

Type

  • mesh:Descriptor

Définition

  • A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

Concept générique

Concepts associés

Synonyme(s)

  • TRIM28 Protein

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-TGHHZ6XH-T

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RDF/XML TURTLE JSON-LD Date de création 11/07/2017, dernière modification le 29/06/2017