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Concept information

Biological Factors > Toxins, Biological > Bacterial Toxins > Botulinum Toxins
Amino Acids, Peptides, and Proteins > Proteins > Bacterial Proteins > Botulinum Toxins
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > Botulinum Toxins
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > Botulinum Toxins

Terme préférentiel

Botulinum Toxins  

Type

  • mesh:Descriptor

Définition

  • Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

Concept générique

Concepts spécifiques

Concepts associés

Synonyme(s)

  • Botulin
  • Botulinum Neurotoxin
  • Botulinum Neurotoxins
  • Botulinum Toxin
  • Clostridium botulinum Toxins

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Toxines botuliniques

    français

  • Bontoxilysine
  • Botuline
  • Toxine botulinique
  • Toxines botuliques
  • Toxines de clostridium botulinum

URI

http://data.loterre.fr/ark:/67375/JVR-V3DSR135-J

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RDF/XML TURTLE JSON-LD Date de création 01/01/1999, dernière modification le 27/05/2020