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... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > Genes > Genes, Neoplasm > Oncogenes > Proto-Oncogenes > Genes, erbA

Terme préférentiel

Genes, erbA  

Type

  • mesh:Descriptor

Définition

  • Genes related to the erbA DNA sequence that was first isolated from the avian erythroblastosis virus (ERYTHROBLASTOSIS VIRUS, AVIAN), v-erbA. In cells, erbA genes encode thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA genes have been identified: erbA-alpha located at 17q21; and erbA-beta located at 3p24. Truncations at the N- and C-terminals of erbA result in products resembling v-erbA. Truncations affect hormone responsiveness but not DNA binding capacity. Viral oncogenes that are homologues of erbA1 (THRA) gene which encodes thyroid hormone receptor alpha. v-erbA Oncogenes potentiate the transforming ability of other oncogenes such as v-erbB by inhibiting spontaneous differentiation of already transformed cells.

Concept générique

Concepts associés

Synonyme(s)

  • erbA Genes

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-VC2HXSBH-L

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RDF/XML TURTLE JSON-LD Date de création 23/05/1994, dernière modification le 08/07/2008