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... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > DNA Sequence, Unstable > Chromosome Fragile Sites

Terme préférentiel

Chromosome Fragile Sites  

Type

  • mesh:Descriptor

Définition

  • Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)

Concept générique

Concepts associés

Synonyme(s)

  • Fragile Sites, Chromosome

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-VWVSVF45-N

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RDF/XML TURTLE JSON-LD Date de création 09/07/2003, dernière modification le 09/07/2013