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Concept information

... > Polycyclic Compounds > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Benzene Derivatives > Benzyl Compounds > Lignans > Podophyllotoxin > Etoposide
Carbohydrates > Glycosides > Glucosides > Etoposide

Terme préférentiel

Etoposide  

Type

  • mesh:Descriptor

Définition

  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Concept générique

Synonyme(s)

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)
  • Demethyl Epipodophyllotoxin Ethylidine Glucoside
  • Eposide

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Étoposide

    français

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)

URI

http://data.loterre.fr/ark:/67375/JVR-WN4RBMR3-B

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RDF/XML TURTLE JSON-LD Date de création 25/07/1975, dernière modification le 01/03/2018