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Concept information

... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Anaphase-Promoting Complex-Cyclosome
Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Anaphase-Promoting Complex-Cyclosome

Terme préférentiel

Anaphase-Promoting Complex-Cyclosome  

Type

  • mesh:Descriptor

Définition

  • An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

Concept générique

Concepts spécifiques

Synonyme(s)

  • Anaphase Promoting Complex

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-WNTTPC8V-K

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RDF/XML TURTLE JSON-LD Date de création 08/07/2013, dernière modification le 02/06/2016