: MeSH: Heteroduplex Analysis

Investigative Techniques > Genetic Techniques > Nucleic Acid Hybridization > Heteroduplex Analysis

Chemical Phenomena > Biochemical Phenomena > Nucleic Acid Hybridization > Heteroduplex Analysis

Heteroduplex Analysis

A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.

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RDF/XML TURTLE JSON-LD Date de création 10/06/1998

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