Passer au contenu principal

Medical Subject Headings (thesaurus)

Choisissez le vocabulaire dans lequel chercher

aligner
annoter
télécharger

Concept information

Cell Physiological Phenomena > Signal Transduction
Chemical Phenomena > Biochemical Phenomena > Signal Transduction

Terme préférentiel

Signal Transduction  

Type

  • mesh:Descriptor

Définition

  • The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Concept générique

Concepts spécifiques

Concepts associés

Synonyme(s)

  • Cell Signaling
  • Signal Transduction Systems

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-Z93C3NZH-L

Télécharger ce concept :

RDF/XML TURTLE JSON-LD Date de création 06/06/1988, dernière modification le 05/07/2019