Concept information
Terme préférentiel
Tetrahydrofolate Dehydrogenase
Type
-
mesh:Descriptor
Définition
- An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Concept générique
Synonyme(s)
- 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
- Dihydrofolate Dehydrogenase
- Dihydrofolate Reductase
- Folic Acid Reductase
Qualificatif(s) autorisé(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
Traductions
-
français
-
5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
-
Dihydrofolate déshydrogénase
-
Tétrahydrofolate déshydrogénase
URI
http://data.loterre.fr/ark:/67375/JVR-Z9XMXKG3-1
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