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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > NLR Proteins > NLR Family, Pyrin Domain-Containing 3 Protein
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > NLR Proteins > NLR Family, Pyrin Domain-Containing 3 Protein

Terme préférentiel

NLR Family, Pyrin Domain-Containing 3 Protein  

Type

  • mesh:Descriptor

Définition

  • An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

Concept générique

Concepts associés

Synonyme(s)

  • Cold Autoinflammatory Syndrome 1 Protein
  • NACHT, LRR and PYD Domains-Containing Protein 3
  • NLRP3 Protein

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-ZZ2T5CN0-4

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RDF/XML TURTLE JSON-LD Date de création 08/07/2016, dernière modification le 24/02/2017