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... > social science subjects > health and social care > health and society > cancer and society > types of cancer > chronic myelogenous leukemia
... > social science subjects > health and social care > health sciences > physiology > physiological processes > health and aging > diseases and medical conditions > types of cancer > chronic myelogenous leukemia
... > other subjects > natural sciences > life sciences > biological sciences > physiology > physiological processes > health and aging > diseases and medical conditions > types of cancer > chronic myelogenous leukemia
... > social science subjects > health and social care > physiology > physiological processes > health and aging > diseases and medical conditions > types of cancer > chronic myelogenous leukemia
... > other subjects > natural sciences > life sciences > biological sciences > biology > physiology > physiological processes > health and aging > diseases and medical conditions > types of cancer > chronic myelogenous leukemia

Preferred term

chronic myelogenous leukemia  

Definition

  • CHRONIC MYELOGENOUS LEUKEMIA (CML) is a malignant clonal disorder of hematopoietic stem cells that results in increases in myeloid cells, erythroid cells, and platelets in the peripheral blood. Philadelphia (Ph) chromosome, formed via translocation t (9; 22), is the cytogenetic hallmark of CML. The translocation forms a chimeric gene, bcr-abl, that generates BCR-ABL, a fusion protein that constitutively activates ABL tyrosine kinase and causes CML. CML has an incidence of 1 to 2 cases per 100,000 people per year and accounts for 15 percent of leukemias in adults. [Source: Encyclopedia of Cancer and Society; Leukemia, Chronic Myelogenous]

Broader concept

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URI

http://data.loterre.fr/ark:/67375/N9J-NM7MFDP8-R

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